By Harry Gelboin
This quantity involves 26 chapters divided into 8 sections in accordance with the next issues: DNA and Chromatin Interactions; Microbial Mutagenesis; Mammalian Mutagenesis; DNA fix; Transformation of Cells in tradition; Animal and Human types; Genetics; and reviews and Observations. The dialogue starts off with an research of the interactions of PAHs with mobile macromolecules and with DNA of mammalian cells in tradition. the next chapters specialise in microbial and mammalian mutagenesis via PAHs; mechanisms of DNA excision fix in human cells; influence of DNA fix at the cytotoxicity and mutagenicity of PAH metabolites in human cells; and oncogenic transformation of cellphone cultures by means of PAHs and their derivatives. the ultimate bankruptcy makes the case for the institution of a approach for undertaking quantitative checks of biomedical chance awarded by way of many sorts of environmental perturbants corresponding to PAHs.
This monograph can be of curiosity to investigators and educators enthusiastic about medical points of PAH examine; govt officers and elected representatives in addition to leaders who needs to confront and resolve the issues on the topic of PAHs; and others within the box of molecular and telephone biology.
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